• BPA (boron phenylalanine):
It can "disguise" itself as an amino acid and is actively taken up by the tumor cells through the highly expressed LAT1 transporter in the cells, accumulating within the cells. However, each molecule contains only one boron atom, resulting in low boron loading efficiency. A large dose is required for administration, and normal tissues also take in a small amount, so safety must be strictly controlled.
• BSH (sodium mercaptododecaborate):
Each molecule contains 10 boron atoms and has good water solubility and extremely low toxicity. It hardly accumulates in normal brain tissue, making it extremely safe. It is particularly suitable for the treatment of childhood brain tumors, but it has insufficient targeting and mainly remains in blood vessels and extracellular matrix.
Clinically, these two drugs are often used in combination to achieve "intracellular + extracellular" dual coverage, improving the uniformity of treatment.
Our company specializes in boron cluster products, which are used by researchers in the development of new boron drugs. If you need any related materials or have any questions, please feel free to contact us.
